Drug Eruption, Unclassified (Pediatric):
A parent's guide to condition and treatment information

If your physician suspects a drug eruption, he or she may want to establish the correct diagnosis by performing a biopsy of the lesion. The procedure involves:

1. Numbing the skin with an injectable anesthetic.
2. Sampling a small piece of skin by using a flexible razor blade, a scalpel, or a tiny cookie cutter (called a "punch biopsy"). If a punch biopsy is taken, a stitch (suture) or two may be placed and will need to be removed 6–14 days later.
3. Having the skin sample examined under the microscope by a specially trained physician (dermatopathologist).

In addition, the doctor may want to do blood tests and look for signs of an allergic reaction.

The best treatment for a drug eruption is to stop the medication that is causing it. After your child stops taking a medicine, it may take 5–10 days to see an improvement in the skin and up to 3 weeks for the rash to go away completely.

Note: Do not have your child stop taking a prescription medication until the doctor advises you to do so.

Other treatments that may be helpful include:

• Oral antihistamine pills or syrups such as diphenhydramine, hydroxyzine, loratadine, cetirizine, fexofenadine, or desloratadine for itching
• Topical corticosteroid (cortisone) creams or lotions for red, inflamed skin
• Topical antibiotic ointments for open sores