This image displays a close-up of the neck showing the typical velvety skin thickening seen in acanthosis nigricans. Acanthosis nigricans, most commonly, is noticed at the armpits and/or neck as a slightly thickened color change, which is sometimes described as appearing "velvety." The darkened color and skin thickening is sometimes subtle in mild and early cases of acanthosis nigricans, as seen here. In addition to the subtle darkening and thickening of the armpit skin caused by acanthosis nigricans, striae (stretch marks) can be seen. This image displays acanthosis nigricans, which affects the body folds, most frequently the neck and armpits. This image displays a skin fold with a rough, "velvety" appearance typical of acanthosis nigricans. This image displays a neck with darker "velvety" skin typical of acanthosis nigricans in a child.
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Picture of Acanthosis Nigricans: This image displays a close-up of the neck showing the typical velvety skin thickening seen in acanthosis nigricans. Divider line
This image displays a close-up of the neck showing the typical velvety skin thickening seen in acanthosis nigricans.
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Treatments Your Physician May Prescribe
Your doctor will certainly try to establish the underlying cause of the acanthosis nigricans. If it is due to obesity, then assistance with weight loss may be in order. If obesity is not a factor, the physician may try to determine an underlying cause by ordering blood work, X-rays, or other diagnostic tests.

Once the underlying medical condition has been established and is being treated, your physician may recommend a topical cream or lotion containing the following:
  • Prescription-strength alpha or beta hydroxy acids (glycolic acid, lactic acid, salicylic acid)
  • Prescription-strength urea
  • A retinoid such as tretinoin, tazarotene, or adapalene
For more severe, stubborn acanthosis nigricans, oral treatments may include:
  • Dietary fish oils
  • Isotretinoin, a very strong medication with many potential side effects, usually used in the treatment of severe, scarring acne
Not usually covered by insurance, some procedures to treat acanthosis nigricans include:
  • Dermabrasion, a mechanical process of controlled, surgical scraping of the skin
  • Lasers, which thin the skin by destroying the uppermost layers
Last Modified: 9 Nov 2007
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